LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Microcrystalline cellulose (C6H10O5)n is refined wood pulp. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . <> cas:9032-51-3 msds CELLULOSE PAB. Truly distinctive drug delivery solutions. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. /Resources 2 0 R 1.3. Eur., JPE . A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. stream The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. 51395-75-6 Avicel RC 591. Quantity: 1 700 kgs. 4 0 obj INCI. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. 2021 Annual Report. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. : 51395-75-6 Date Approved: 01/31/2008 Revision No. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. }o]X4]. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. High performance lubricant that brings more to the tablet. Safety Data Sheet for Cellulose microcrystalline 102331. q9;v80 Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. <> EINECS #: 232-674-9 1.7. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. CAS 9004-34-6, pH 5 - 7.5. Catalog Number 102331. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. In 1964 FMC, Corporation . They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. <> FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Microcrystalline Cellulose / Avicel PH-102. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" The most. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. It is a white, free-flowing powder. };khd5x=fr However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? It is also inert and biocompatible. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Millipore. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. 102331. However, consumption of large quantities of the material may have a laxative effect. Watch Now. Some substance identifiers may have been claimed confidential, or may . Quick Links. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Validity Area. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. It works as a moisture sponge and permits the controlled growth of spheroids. <> Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Medium size standard MCC grade, suited for the majority of directly compressible actives. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Are you sure you want to delete your template? A., and Smith, P. A. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Battista, O. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Document(s): certificate data msds. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. G2W4de=u183KGH{ vQ#4:1\wc /Parent 3 0 R HMo@9, U Q!R/1*;` ChemicalBook. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. MCC helps in the formation of spheres because of its . Microcrystalline Cellulose Side Effects. Explore how you can develop your career and bring your creative ideas to life at IFF. X\o^ Wu, K. Zuurman, H.W. P}MFbN#[>r(y Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. endobj Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. JFIF ` ` ZExif MM * J Q Q Q C The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. %PDF-1.4 cas:9000-11-7 msds Carboxymethyl cellulose. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Browse Avicel PH-101 and related products at MilliporeSigma. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. These, in turn, are assembled into fibrils in the cell wall. All rights reserved. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. If breathing is difficult or if . Your file is uploaded and ready to be published. Safety Data Sheet (SDS) Viewer. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Manufacturer: FMC BioPolymer. Gloves, eye protection and a dust mask should be used. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Well-recognized product that can do it all. LOT #: Available upon request. 1. /MediaBox [0 0 612 792] Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Cellulose microcrystalline for column chromatography. Home. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . There may be more fiber in your food than you realized. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. B;vLZpHU%ChUyD+[ . gac74 [#B6`Wnw7 endstream An agricultural sciences company. Chemical Formula: (C6H10O5)n 1.4. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. SUBSTANCE IDENTIFICATION 1.1. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Go to Investor Relations. endobj The short-term limit for total inhalable dust is 20 mg/m3. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Learn about FMC's industry leading goal of net-zero emissions by 2035. % Avicel PH-101. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. 2 0 obj % This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. We respect your privacy FMC Privacy Policy. Production of Pharmaceutical Grade Microcrystalline Cellulose. EMCOCEL 90 M. 130. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . q9;v80q>jZ SDS - Safety Data Sheet. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . BIOACCUMULATIVE POTENTIAL Product Name: Microcrystalline Cellulose 1.2. . No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Buy Chemicals. Van Veen, G.K. Bolhuis, Y.S. . Avicel PC 611 (FMC Biopolymer) Supplied by. Are you looking for information about products and services by region? (Microcrystalline Cellulose Market Pr. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Page 1 of 8. The cellulose molecule is formed through repeated condensation of cellobiose units. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . No. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Microcrystalline Cellulose NF. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Chemical Formula: (C6H10O5)n 1.4. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility.