Fink BN, Steck SE, Wolff MS, et al. Chen J, Power KA, Mann J, et al. While choosing an Omega 3 supplement, it is . Mol Nutr Food Res 2009;53:1366-75. Possible interactions include: . or aspirin. Flaxseed is a good source of dietary fiber. Some people use black seed oil supplements to treat certain health conditions, including arthritis, allergies, asthma, and diabetes, and maintain a healthy weight. Other drugs may interact with flax, including prescription and over-the-counter medicines, vitamins, and herbal products. One tablespoon of flaxseed oil has 7.26 grams. Learn about the medical uses, claims, and side effects of flaxseed. 5 Science-Based Benefits of 5-HTP (Plus Dosage and Side Effects), The 15 Best Vitamin Brands of 2023: A Dietitians Picks, Red Raspberry Leaf Tea: Pregnancy, Benefits, and Side Effects. Research on the use of flaxseed and flaxseed oil for specific conditions shows: When used in combination with daily exercise and a low cholesterol diet, flaxseed might help control cholesterol levels. Touillaud MS, Thiebaut AC, Fournier A, et al. View abstract. View abstract. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Nutr Rev 2004;62:18-27. Often youll need to take flaxseed oil a few hours before administering medications to make sure your body absorbs them properly. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Yari Z, Rahimlou M, Poustchi H, Hekmatdoost A. Flaxseed supplementation improves anthropometric measurements, metabolic, and inflammatory biomarkers in overweight and obese adults. Epiandrosterone . J Altern Complement Med 2021;27(10):824-831. Taking flaxseed by mouth seems to help reduce, Breast pain (mastalgia). Mayo Clinic does not endorse any of the third party products and services advertised. Flaxseed oil, the most commonly used high risk supplement that contains phosphorus, was taken by 16 percent of patients with normal or mildly reduced kidney function. Sorry, we have no data available. Alonso L, Marcos ML, Blanco JG, et al. Omega 3 dietary sources include flax seeds, chia seeds, walnuts, and fish. Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (mcf-7) in nude mice. Therapeutic Research Faculty 2020. View abstract. J Diet Suppl 2011;8:257-65. View abstract. Barbiturate medicines that are prescribed for treating insomnia, controlling anxiety, or treating seizures may interfere with the effectiveness of the birth control pill. View abstract. Taking flaxseed along with diabetes medications might cause blood sugar to drop too low. Exp Biol Med (Maywood) 2007;232:1071-80. Int J Prev Med. Ramon JM, Bou R, Romea S, et al. View abstract. The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. It is created by eHealthMe based on reports of 30 people who take . Flaxseed oil is available in liquid and capsule form. For this reason, it is critical to discuss possible interactions with Trulicity before you start treatment with it. Limited animal studies have found that flaxseed and flaxseed oil do not interfere with actions of tamoxifen or trastuzumab (medications used for breast cancer treatment) and may even enhance their effectiveness. When taken in recommended amounts, flaxseed and flaxseed oil are generally safe to use. Do not use extra flax to make up the missed dose. Alvarez-Perea A, Alzate -Prez D, Doleo Maldonado A, Baeza ML. View abstract. Urology 2001;58:47-52. Flaxseed may interfere with the absorption of some medications. View abstract. View abstract. Dietary flavonoid intake and breast cancer risk among women on Long Island. Alpha-linolenic acid in the treatment of rheumatoid arthritis. 2016 Jun;67(4):461-9. Explore (NY) 2021. The Mayo Clinic warns that using flaxseed oil with this blood thinner, or any other anticoagulant, may increase your risk of bleeding. Hypertension. Haidari F, Banaei-Jahromi N, Zakerkish M, Ahmadi K. The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Clin Cancer Res 2005;11:3828-35. Am J Clin Nutr 2004;79:318-25.. View abstract. Use caution when adding flaxseed oil to your diet or using it as a supplement. If you need surgery, dental work, or a medical procedure, stop taking flax at least 2 weeks ahead of time. 4. Black Seed Oil and Diabetes: What's Known, What's Not, Harvard T.H. Carcinogenesis 1996;17:1373-6. Dont take flaxseed oil or flax seeds in pregnancy or while breastfeeding. The side effects of flaxseed oil may lead to adverse reactions if you consume it and take certain medications or have particular medical conditions. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Medications taken by mouth (Oral drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Ann Nutr Metab 2000;44:263-5. View abstract. View abstract. You should also discuss the length of time its healthy to use it as well as a recommended dosage. Moreover, the National Center for Biotechnology Information shared an article from the Division of Natural Products, which is a branch of the Food and Drug Administration, agreeing with the dangers that flaxseed can have on the . The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Eating flaxseeds can have gastrointestinal side effects and can significantly increase the number of bowel movements you have in a day. But what you might not realize is that flaxseed contains very large amounts of lignans and phytoestrogens, making it one of the most estrogenic foods around. 2016 Feb;25:90-5. View abstract. Effect of a homemade salivary substitute prepared using chamomile (Matricaria chamomilla L.) flower and flax (Linum usitatissimum L.) seed to relieve primary burning mouth syndrome: a preliminary report. View abstract. Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. It is not known whether flax passes into breast milk or if it could harm a nursing baby. Yes: Flaxseed may interact with acetaminophen, certain antibiotics, estrogens, furosemide, Ketoprofen, diabetes medication, anticoagulants & Metoprolo. Circulating enterolactone and risk of endometrial cancer. Flaxseed and flaxseed oil. However, it may cause undesirable side effects if you have a preexisting medical condition, use certain medications, or take the wrong dosage. Teas have been used as a natural remedy to soothe stomach upset for thousands of years. Patade A, Devareddy L, Lucas EA, et al. Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W. Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. It is better to start with a low dose of flaxseed because of its fiber content and slowly increase the amount. https://nccih.nih.gov/research/results/spotlight/062308.htm. 2013 May;33(5):367-75. Dietary flaxseed independently lowers circulating cholesterol and lowers it beyond the effects of cholesterol-lowering medications alone in patients with peripheral artery disease. View abstract. View abstract. Flaxseed oil might lower blood pressure. 2015;145:758. those that regulate blood sugar, including. Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled, crossover trial. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Systemic lupus erythematosus (SLE) nephritis, Constipation. Brouwer IA, Katan MB, Zock PL. How fast does psyllium work? Drug interactions are reported among people who take Flax seed and Aspirin. Avoid using flax together with other herbal/health supplements that can lower blood sugar, such as alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others. Version: 5.01. prednisone, atorvastatin, rosuvastatin, simvastatin, ezetimibe, estradiol, Crestor, MiraLAX, Colace, docusate. Examples of barbiturates and medications that have barbiturate actions include: Felbatol (felbamate) Br J Nutr 2008;101:1145-9. 2020;152:104622. This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Eating flaxseed in muffins or other foods seems to increase, High cholesterol. View abstract. The adequate intake (AI) for omega-3 fatty acids is 1.6 grams for men and 1.1 grams for women. Am J Clin Nutr 2006;84:400-5. Flaxseed oil contains a-linolenic acid (ALA), which the body can break down into an omega-3 fatty acid. Anaphylaxis caused by flaxseed. Fish Oil Dosage: How Much Should You Take Per Day? View abstract. View abstract. View abstract. Ultimately, if flaxseed is to blame, an upped dosage of levothyroxine medication is probably needed going further. Laaksonen DE, Laukkanen JA, Niskanen L, et al. J Med Food. A prospective study of dietary fat and risk of prostate cancer. According to WebMD, "Research suggests that plant omega-3s help the cardiovascular system through several different mechanisms, including anti-inflammatory action and normalizing the heartbeat. Chen J, Power KA, Mann J, et al. Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Nutr Cancer 1992;17:153-9. Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. View abstract. View abstract. Lemay A, Dodin S, Kadri N, et al. Here are 5 potential benefits of 5-HTP, Ritual is a subscription-based vitamin company that offers protein powders and multivitamins for people of all ages. View abstract. Flaxseed is packed with beneficial nutrients, omega-3 fatty acids, and fiber. Ingredients: Stichopus Horrens Extract: Gamodulin Chlorella Vitamin E (dl-alpha-tocopherol) Flaxseed oil Direction Of Use: Adult 15ml each time, twice a day Twice a day preferably to be taken on empty stomach. ", Kardiologia Polska: "Linseed Oil Increases HDL3 Cholesterol and Decreases Blood Pressure in Patients Diagnosed With Mild Hypercholesterolaemia", Phytotherapy Research: "A Comparison Between the Effects of Flaxseed Oil and Fish Oil Supplementation on Cardiovascular Health in Type 2 Diabetic Patients With Coronary Heart Disease: A Randomized, Double-Blinded, Placebo-Controlled Trial", U.S. National Library of Medicine: "Warfarin". Common interactions include fatigue among females and drug ineffective among males. Lucas EA, Wild RD, Hammond LJ, et al. . View abstract. Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study. Therefore, the quality and contents of flaxseed oil arent regulated and standardized. J Natl Cancer Inst 1993;85:1571-9. Diabetes drugs. Cancer Epidemiol Biomarkers Prev 2000;9:719-25. information highlighted below and resubmit the form. Not all possible interactions are listed in this product guide. health information, we will treat all of that information as protected health View abstract. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Oral drugs. Flaxseed oil may also lower insulin and improve antioxidant activity in people with Type 2 diabetes, according to a July 2019 randomized, double-blind, placebo-controlled study published in Phytotherapy Research. Am J Epidemiol 2007;165:514-23. View abstract. Mani UV, Mani I, Biswas M, Kumar SN. You should consume water regularly if you use flax seeds as a supplement. J Nutr. J Nutr 2008;138:938-45. Therefore, using flaxseed oil to relieve your bowels will not have the same effect as using flax seeds. Accessed Sept. 27, 2017. Suzuki R, Rylander-Rudqvist T, Saji S, et al. Though your body contains enzymes that convert ALA from flaxseed oil into EPA and DHA, your body only converts 10 to 15 percent of the ALA, says Harvard Health Publishing. Do not take flax without medical advice if you are using any of the following medications: any medications for diabetes or high blood pressure; This list is not complete. To help you remember, take it at the same time(s) each day. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Cunnane SC, Ganguli S, Menard C, et al. include protected health information. J Altern Complement Med 2020;26(9):799-806. May cause allergic reactions. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. View abstract. There is a high chance you may have an allergy to flaxseeds and flaxseeds oil. Urology 2004;63:900-4.. View abstract. DOI: What are omega-3 fatty acids from fish oil? the unsubscribe link in the e-mail. View abstract. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. View abstract. Fact Checked by Paul Bossung. Selected from data included with permission and copyrighted by First Databank, Inc. You can find flaxseed oil in oil form, in capsules, or even in enriched food products. National Center for Complementary and Integrative Health. Sun J, Bai H, Ma J, et al. View abstract. Summary: Drug interactions are reported among people who take Flaxseed and Metformin. Medications are the primary treatment for hypertension; however, adherence to drug regimens is low (~50 %). Polypodium Leucotomos - Inotersen. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Flaxseed and flaxseed oil (Linum usitatissimum). However, NCCIH says the evidence that flaxseed oil has health benefits is conflicting, and more research is needed before claims can be made. View abstract. View abstract. View abstract. Skip the missed dose if it is almost time for your next scheduled dose. JAMA 2005;294:1493-1504. Drug class: Herbal products. Do not use more of this product than is recommended on the label. Adlercreutz H, Heikkinen R, Woods M, et al. Flaxseed might also be helpful for managing diabetes and lowering the risk of heart disease. Adolescent dietary phytoestrogen intake and breast cancer risk (Canada). does flaxseed interfere with blood pressure medication Master, I m hungry. Clin Cancer Res 2004;10:7703-11. But before you take some, you decide to do some research on the interactions it may have with some of the medications you are currently taking. Dodin S, Lemay A, Jacques H, et al. There is a chance you may have an allergy to flax seeds and flaxseed oil. Summary: Drug interactions are reported among people who take Flaxseed and Anastrozole. Possible drug interactions: Can reduce blood levels and effectiveness of many drugs, including birth control pills, cholesterol-lowering statins and some anti-HIV drugs. 2013 Apr;16(4):357-60. Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Ahmadpour P, Javadzadeh Y. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. Nutritional attributes of traditional flaxseed in healthy young adults. are using nonsteroidal anti-inflammatory drugs. 2020:1-9. Mayo Clinic does not endorse companies or products. Cabbage - Sulconazole. Hedelin M, Lof M, Olsson M, et al. Enterolactone is differently associated with estrogen receptor beta-negative and -positive breast cancer in a Swedish nested case-control study. Soltanian N, Janghorbani M. Effect of flaxseed or psyllium vs. placebo on management of constipation, weight, glycemia, and lipids: A randomized trial in constipated patients with type 2 diabetes. You should discontinue and avoid the use of flaxseed oil if you notice itching, swelling, redness, or hives when you ingest it. Lim TL, Pietrofesa RA, Arguiri E, et al. View abstract. Arjmandi BH. Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. Anaphylaxis caused by linseed (flaxseed) intake. The use of flax seeds or flaxseed oil may result in lowered blood sugar. All rights reserved. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. This is not a complete list of side effects and others may occur. J Steroid Biochem 1986;25:791-7.. View abstract. A total of 12 drugs are known to interact with green tea. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. Eating a flaxseed muffin daily for 3 months or taking flaxseed powder by mouth daily for 2 months seems to reduce breast pain that occurs at the start of the, Obesity. Variability in anticancer lignan levels in flaxseed. Lancet 1982;2:1295-9. You may find that flaxseed oil leads to diarrhea. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. It is not intended to replace professional veterinary advice or care. J Am Coll Nutr 2001;20:398S-402S. Nutr J. Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome. Adlercreutz H, Fotsis T, Bannwart C, et al. View abstract. Low adherence may be a contributing factor leading to uncontrolled blood pressure in patients. 1. View abstract. View abstract. View abstract. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Allergol Immunopathol (Madr) 2003;31:47-9. . Yari Z, Rahimlou M, Eslamparast T, Ebrahimi-Daryani N, Poustchi H, Hekmatdoost A. Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. Int J Cancer 2006;119:2376-81. Flax seeds are considered to help with constipation. Am J Clin Nutr 1999;69:395-402. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Steroid Biochem Mol Biol 1994;50:205-12.. View abstract. What medications does flaxseed interfere with? List Flaxseed side effects by likelihood and severity. Read More Created for people with ongoing healthcare needs but benefits everyone. When considering the use of herbal supplements, seek the advice of your doctor. However, you should always talk to your primary care provider to discuss flaxseed oil dosage and safety before adding the plant oil to your daily routine. Certain herbal supplements, such as St. John's wort, may decrease blood levels of some statin drugs, and when taken with atorvastatin, may . J Nutr 2010;140:1937-42. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. https://naturalmedicines.therapeuticresearch.com. Effects of dietary flaxseed in women with cyclical mastalgia. View abstract. Rickard SE, Yuan YV, Thompson LU. Human metabolism of mammalian lignan precursors in raw and processed flaxseed. J Nutr 2010;140:293-7. Some medications that may interact with flaxseed oil negatively include: You should consult your doctor before using flaxseed oil if you have: Pregnant and nursing women should avoid the use of flaxseed oil. The phase IV clinical study analyzes what interactions people who take Flaxseed and Metformin have. J Clin Oncol 2007;25:648-55. 2017 Sepl18(9):1096-1107. View abstract. Bierenbaum ML, Reichstein R, Watkins TR. Haghighatsiar N, Askari G, Saraf-Bank S, Feizi A, Keshmiri H. Effect of flaxseed powder on cardiovascular risk factor in dyslipidemic and hypertensive patients. Cancer Epidemiol Biomarkers Prev 2006;15:1132-6. View abstract. Cockerell KM, Watkins AS, Reeves LB, et al. J Am Coll Nutr 1993;12:501-4. These blood-thinners are broken down in the body by the liver enzyme CYP3A4. Flax has also been used to treat osteoporosis. View abstract. Flaxseed oil may cause complications with women who are pregnant because of its ability to affect hormones. Flaxseed oil is a supplement that can boost your intake of omega-3 fatty acids. Wang C, Makela T, Hase T, et al. The phase IV clinical study analyzes what interactions people who take Flaxseed and Anastrozole have. View abstract. 2019;38(7):1961-1969. J Nutr. View abstract. Click here for an email preview. The use of flax seeds may increase your chances of bleeding. The information provided in this blog post is intended for informational purposes only and should not be used to diagnose, treat, cure, or prevent any health condition in animals. The phase IV clinical study analyzes what interactions people who take Flax seed and Aspirin have. Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. 2014 Jul;64(1):53-9. Medically reviewed by Drugs.com on Jul 25, 2022. Bloedon LT, Balikai S, Chittams J, et al. National Center for Complementary and Integrative Health. People use flaxseed and flaxseed oil to reduce cholesterol and blood sugar and treat digestive conditions. 2021;75(1):99-111. View abstract. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. The evidence is mixed as to whether flaxseed or flaxseed oil has any effect on the prostate or the risk of prostate cancer. Beta . Flaxseed might lower blood pressure. Using different formulations together increases the risk of an overdose. Mohammadi-Sartang M, Sohrabi Z, Barati-Bodaji R, Raeisi-Dehkordi H, Mazloom Z. Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Taking flaxseed along with medications that lower blood pressure might cause blood pressure to go too low. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. Flaxseed interacts with 583 drugs . J Clin Endocrinol Metab 2002;87:1527-32.. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Flaxseed interacts with 583 drugs . What Are the Benefits of Flaxseed Oil Pills? Br J Nutr 1993;69:443-53. Does Flaxseed Interfere With Cholesterol Medication? Zeleniuch-Jacquotte A, Lundin E, Micheli A, et al. There is a problem with View abstract. View abstract. 2013 Apr;17(2):275-81. Flaxseed can be added to hot cereal, muffins, pancakes, salads, salad dressings, yeast breads and more. Possible interactions include: Anticoagulant and anti-platelet drugs, herbs and supplements. J Womens Health (Larchmt) 2008;17:355-66. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Complement Ther Med. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. A September 2014 article published in the Journal of Food Science and Technology says flaxseed oil is the best plant source of the essential fat. Eur J Clin Nutr 1998;52:749-53. The authors of the article in the Journal of Food Science and Technology call flaxseed oil a functional food because of its potential health benefits. This includes angelica (dong quai), capsicum, clove, danshen, garlic, ginger, ginkgo, horse chestnut, panax ginseng, poplar, red clover, saw palmetto, turmeric, and willow. View abstract. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Reducing atherogenic risk in hyperlipemic humans with flaxseed supplementation: a preliminary report. 2020;19(1):8. are using cholesterol-lowering drugs. 2015 Apr;145(4):758-65. Estrogens. 2019;73(2):258-265. Reprod Toxicol 2007;23:397-406. Appetite 2012;58:490-5. Drink plenty of water each day while you are taking this product. Nutr Cancer 1990;13:1-8.. View abstract. Taylor, C. G., Noto, A. D., Stringer, D. M., Froese, S., and Malcolmson, L. Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. Refrigerated flaxseed should be used within 30 days of being ground, and frozen flaxseed should be used within 45 days of storing.