Mountain lions, a bobcat, red foxes, black bears, and skunks represent the latest avian flu cases in mammals. B., Lewis. Selected counties in California, Colorado, Connecticut, Georgia, Iowa, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah (https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm). We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Background: Risk stratification models have been developed to identify patients that are at a higher risk of COVID-19 infection and severe illness. Two new observational studies suggest that COVID-19 vaccination lowers long-COVID incidence and severity. Sect. Selected counties in California, Colorado, Connecticut, Georgia, Iowa, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah (https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm).
The success of Covid-19 vaccines against omicron: Vaccinated up to five To obtain From this cohort, the study excluded the following infants born to (1) mothers who were not between ages 16 and 50 years at pregnancy onset; (2) mothers who did not have a primary KPNC facility assignment; (3) mothers who were not continuous KPNC members from December 15, 2020 until delivery; (4) mothers who had a positive nasal/throat swab for SARS-CoV-2 by polymerase chain reaction (PCR) prior to pregnancy onset; (5) mothers who had a positive SARS-CoV-2 antibody test documented by KPNC prior to the onset of pregnancy; (6) mothers who received one or more doses of COVID-19 vaccine prior to pregnancy onset. CAS The increase in transmissibility of the Omicron variant might have amplified these risks for hospitalization, resulting in increased hospitalization rates among Black adults compared with White adults, irrespective of vaccination status. Using previously described methods (3), investigators collected clinical data on a representative sample of adult patients (7.9%) hospitalized during July 1, 2021January 31, 2022, stratified by age and COVID-NET site. A and B, Markers indicate estimates, with vertical lines indicating 95% CIs. During the Delta dominant period, the crude incidences of testing positive for SARS-CoV-2 during the first 2, 4, and 6 months of life were lower among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy (0.75, 1.43, and 1.56 infants per 100 person-years [PY], respectively) than those whose mothers were not vaccinated during pregnancy (5.47, 5.10, and 4.78 infants per 100 PYs, respectively). As a result, the number of total hospitalizations exceeds the sum of unvaccinated adults, adults who received a primary series without a booster or additional dose, and adults who received a primary series with a booster or additional dose. The mean age at pregnancy onset was 31.62 years (standard deviation of 4.66 years). If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Open 5, e2232760 (2022). The vaccines have proved highly safe and effective at reducing the risk of severe illness, hospitalization and death. * https://covid.cdc.gov/covid-data-tracker/#variant-proportions, https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covid-net/purpose-methods.html. https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb. Persons who received only 1 vaccine dose of a 2-dose series 14 days before the SARS-CoV-2 test date or had received a single dose of either a 1- or 2-dose vaccination series <14 days before the positive SARS-CoV-2 test result were considered partially vaccinated and were not included in rates by vaccination status. Most mothers (1032 of 1138) who received only one dose received the vaccine during the third trimester. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19COVID-NET, 13 states, March 1August 22, 2020.
CDC study finds shorter hospital stays during omicron wave, even as A recent study found that the mean titer of maternally derived antibodies in infants of vaccinated mothers were higher at age 2 months compared with antibody titers at age 6 months23. However, these Omicron impacts have been mostly observed in countries with high vaccination rates in the Region: the comparatively lower rate of hospitalizations and deaths so far is in large part thanks to vaccination, particularly of vulnerable groups. Thompson, M. G. et al. Wkly. 384, 22732282 (2021). New charts from the Centers for Disease Control and Prevention (CDC) showed that hospitalization rates were much lower among those who were vaccinated even as Omicron was sweeping the nation. N. Engl. Among all adults, relative to the Delta-predominant period, COVID-19related illness was the primary reason for admission for a smaller percentage of hospitalizations (87.5% versus 95.5%, p<0.01), and median length of stay was shorter (4 versus 5 days, p<0.01) during the Omicron-predominant period; during this period, the proportion of patients admitted to an intensive care unit, who received invasive mechanical ventilation, and who died in-hospital decreased significantly (all p<0.01). Data were available for researchers who meet the criteria for access to Kaiser Permanente Northern California confidential data. "The high hospitalization rates in unvaccinated compared with vaccinated persons with and without a booster dose underscores the importance of COVID-19 vaccinations in preventing hospitalizations and suggests that increasing vaccination coverage, including booster dose coverage, can prevent hospitalizations, serious illness, and death," the researchers wrote. Percentages presented were weighted to account for the probability of selection for sampled cases (3). Defined as one or more of the following: chronic lung disease including asthma, chronic metabolic disease including diabetes mellitus, blood disorder/hemoglobinopathy, cardiovascular disease, neurologic disorder, immunocompromising condition, renal disease, gastrointestinal/liver disease, rheumatologic/autoimmune/inflammatory condition, obesity, feeding tube dependency, and wheelchair dependency. When possible, CDC associates a persons primary vaccination series and booster dose with that person. Hospitalisation associated with SARS-CoV-2 delta variant in Denmark. Article These findings are consistent with the diminishing of pregnancy-derived antibodies in infants over time22. The remaining authors declare no competing interests. Morb. Pediatr. Vaccination status is not available for Iowa and cases from Iowa are excluded from analyses that examined vaccination status. Implementing strategies that result in the equitable receipt of COVID-19 vaccinations, through building vaccine confidence, raising awareness of the benefits of vaccination, and removing barriers to vaccination access among persons with disproportionately higher hospitalizations rates from COVID-19, including Black adults, is an urgent public health priority. Open 5, e2233273 (2022). These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Centers for Disease Control and Prevention. J. Med.
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Adults who received booster doses were classified as those who completed the primary series and received an additional or booster dose on or after August 13, 2021, at any time after completion of the primary series, and 14 days before a positive test result for SARS-CoV-2, because COVID-19associated hospitalizations are a lagging indicator and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). COVID-19Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status COVID-NET, 14 States, July 2021January 2022. 9-14 As of October 2022, 68% of the US population has completed primary series vaccination. and B.F. P.R. COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19associated hospitalizations in 99 counties across 14 states. COVID-19associated hospitalizations are those occurring among residents of a predefined surveillance catchment area who have a positive real-time reverse transcriptionpolymerase chain reaction (RT-PCR) or rapid antigen detection test result for SARS-CoV-2 during hospitalization or the 14 days preceding admission. Ann Intern Med 2021;174:140919. These cookies may also be used for advertising purposes by these third parties. Morb. Maternal vaccination and risk of hospitalization for Covid-19 among infants. TN, NMF, SGN, DDA, AMP, and ST wrote the original draft of the manuscript.
COVID hospitalizations amid omicron 23 times higher among - ABC News Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. After the emergence of the Omicron variant, the rate of COVID-19 hospitalizations in the United States was 10.5 times higher in unvaccinated adults and 2.5 times higher in those who were vaccinated but received no booster than in booster recipients, according to a new study. Monthly incidence is based on SARS-CoV-2 positive test result date or, if not known, hospital admission date. Google Scholar. Kim, L. et al. Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis.
Vaccines and Omicron mean Covid now less deadly than flu in England Klein, N. P. et al. mmwrq@cdc.gov. The study was funded by the National Institute of Allergy and Infectious Disease grant # 1R01AI168373-01 to O.Z. Informed consent was waived because this was a data-only study with no direct contact with participants. Without the vaccines many more people would likely be in hospital. Mortal. Racial and ethnic disparities in rates of COVID-19associated hospitalization, intensive care unit admission, and in-hospital death in the United States from March 2020 to February 2021. Sect. Overall, 63% of Americans are fully vaccinated. It is critical that nursing home residents stay up to date with CO VID-19 vaccines and receive a bivalent booster dose to maximize protection against COVID-19. The Spanish Health Ministry also publishes hospitalization data throughout Spain broken down by vaccination status, although in this case it is based on estimates: to calculate the number of unvaccinated in each age group, they subtract the number of vaccinated from the population in 2020.However, the target population will have grown since then, so it is possible that the ministry's . PubMedGoogle Scholar. Over the entire study period, the crude rate of hospitalization with a SARS-CoV-2 positive test was lower during the first 6 months of life among infants whose mothers received at least two doses . Article Additional recommendations followed and data availability on booster-dose status varies by age because not all age groups were recommended by ACIP to receive booster doses at the same time. The objective of this study was to further evaluate the effectiveness of at least two doses of mRNA COVID-19 vaccination during pregnancy for preventing SARS-CoV-2 infection in infants during the first 2, 4, and 6 months of life during the Delta and Omicron variant periods.
Omicron Is Not More Severe for Children, Despite Rising Moline HL, Whitaker M, Deng L, et al. J. Med.
Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV Gynecol. Receipt of COVID-19 vaccine during pregnancy and preterm or small-for-gestational-age at birtheight integrated Health Care Organizations, United States, December 15, 2020-July 22, 2021. The research was published yesterday in JAMA Internal Medicine.
Effectiveness of first and second COVID19 mRNA vaccine monovalent conducted all statistical analysis in collaboration with O.Z. 226, 236 e1236.e14 (2022).
45 C.F.R.
Hospitalizations of Children Aged 5-11 Years with Laboratory 40, e137e145 (2021). Although both approaches adjusted for the same confounding factors, the effectiveness estimates from the TND were higher than those from the cohort design, which is consistent with our previous analyses of influenza vaccine effectiveness in which we also observed that the TND tended to result in higher vaccine effectiveness estimates than did our cohort analyses30. Provided by the Springer Nature SharedIt content-sharing initiative. Mortal. Polack, F. P. et al. All these results were similar to those when no adjustments for covariates are made (Supplemental Table1). Mortal. In conclusion, in this population-based cohort study, we found that infants born to mothers who received at least two doses of an mRNA COVID-19 vaccine during pregnancy were at lower risk of testing positive for SARS-CoV-2 and were at lower risk of hospitalization during the first 6 months of life compared with infants whose mothers were unvaccinated during pregnancy. T.R. Just 28% of children in the age group - around 8 million . Access your favorite topics in a personalized feed while you're on the go. Mortal. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19COVID-NET, 14 States, March 1-July 25, 2020. BNT162b2 vaccine effectiveness against omicron in children 5 to 11 years of age. To account for the correlation between infants with the same mother, we fit marginal Cox proportional hazards models using robust sandwich variance estimates. Vaccine 40, 656665 (2022). References to non-CDC sites on the Internet are
2022 The Authors. COVID-19 vaccines have demonstrated both high efficacy in clinical trials and high real-world effectiveness, especially against the original and Delta variant of the virus6,7,8,9,10. Another explanation is the presence of a high COVID-19 vaccination rate among studied individuals (more than two-thirds), which is supported by the finding that the majority of patients had been infected with SARS-CoV-2 prior to undergoing vaccination. With wave after wave of SARS-CoV-2 variants, COVID-19 patients filled the worlds' hospitals and morgues because not everybody had access to vaccines or were willing to be vaccinated.
COVID-19-Associated Hospitalizations Among Adults During SARS-CoV-2 Risk of hospitalization and vaccine effectiveness among COVID-19 61) indicates a lower risk of hospitalisation with omicron versus delta, averaging over all age groups and vaccination strata. Maternal vaccination with at least two doses reduced the infants risk of testing SARS-CoV-2 positive initially by 84% which decreased to 56% by 6 months of life in the Delta dominant period. Statistical codes are not publicly available but are available from the corresponding author. Infants were followed from birth until the first positive SARS-CoV-2 test by PCR at age 2, 4, or 6 months, with censoring due to death, health plan disenrollment, or end of follow-up (May 31, 2022). TN, NMF, WH, and SA wrote the software. Am. Cite this article. Sarah J. BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting. Most hospitalized children were unvaccinated, and nearly one in three were Black. During the period of Omicron predominance, hospitalization rates increased most sharply among Black adults in the United States relative to all other racial and ethnic groups examined and reached the highest rate observed among all racial and ethnic groups since the beginning of the pandemic. SARS-CoV-2 delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. Our findings that receipt of at least two doses of COVID-19 vaccine during pregnancy was effective at protecting infants during the Delta period are similar to those reported in a recent Norwegian study showing that mRNA COVID-19 vaccination during pregnancy was associated with a 71% decreased risk of testing positive for SARS-CoV-2 in infants during their first 4 months of life during the Delta period17. Sign up for notifications from Insider! Nature Communications (Nat Commun) Morb. Vaccine 35, 58505857 (2017). JAMA Netw. Proportions between the pre-Delta and Delta period were compared using chi-square tests; p-values <0.05 were considered statistically significant, adjusted for multiple comparisons using the Bonferroni correction method. 386, 15321546 (2022). 384, 403416 (2021). Starting the week ending December 4, 2021, Maryland data are not included in calculations but are included in previous weeks. PubMed Central Danino, D. et al. The exposure of interest was mRNA COVID-19 vaccination status during pregnancy in the electronic health record. SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland, Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy, Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel, Covid-19 vaccination programme effectiveness against SARS-CoV-2 related infections, hospital admissions and deaths in the Apulia region of Italy: a one-year retrospective cohort study, Post-vaccination outcomes in association with four COVID-19 vaccines in the Kingdom of Bahrain, Effectiveness and protection duration of Covid-19 vaccines and previous infection against any SARS-CoV-2 infection in young adults, The indirect effect of mRNA-based COVID-19 vaccination on healthcare workers unvaccinated household members, SARS-CoV-2 infection and COVID-19 vaccination in pregnancy, Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar, https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765, https://doi.org/10.1016/j.jpeds.2022.09.059, http://creativecommons.org/licenses/by/4.0/. On 13 December, Denmark released data showing that hospitalization rates for people infected with Omicron seemed to be on a par with those for people infected with other variants. Foo, D., Sarna, M., Pereira, G., Moore, H. C. & Regan, A. K. Longitudinal, population-based cohort study of prenatal influenza vaccination and influenza infection in childhood.
Unvaccinated Children Hospitalized at Twice the Rate During Omicron However, infants aged <6 months are not currently eligible for any currently available COVID-19 vaccines and must rely on placentally acquired immunity from their mothers. supervised chart reviews. Severe cases may increase in the wake of holiday parties where people of all ages mixed. Includes current treatment or recent diagnosis within the previous 12 months of an immunosuppressive condition or use of an immunosuppressive therapy. Although the study was unable to directly estimate VE against hospitalization due to the small number of hospitalized cases, it found that over the entire study period, the incidence rate of hospitalization during the first 6 months of life was much lower among the infants whose mothers were vaccinated during pregnancy compared with those whose mothers were not vaccinated. J. Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. PubMed This conversion might result in character translation or format errors in the HTML version. Hospitalizations rates increased among all adults irrespective of vaccination status (unvaccinated, primary series only, or primary series plus a booster or additional dose). These persons are excluded from the proportions of race/ethnicity but are included in other analyses. Science brief: omicron (B.1.1.529) variant. In this design, we used Cox proportional hazards models with calendar days as the underlying scale to estimate hazard ratios and calculated vaccine effectiveness as 1 minus the hazard ratio. SARS-CoV-2 variants of concern and variants under investigation in England: technical briefing 35. All information these cookies collect is aggregated and therefore anonymous. PubMed DOI: http://dx.doi.org/10.15585/mmwr.mm7112e2. Rates are calculated using the CDC National Center for Health Statistics vintage 2020 bridged-race postcensal population estimates for the counties included in surveillance. J. Med. Buchan, S. A. et al. Adults with a positive result whose SARS-CoV-2 test date was 14 days after the first dose of a 2-dose series but <14 days after receipt of the second dose were considered partially vaccinated. These data should be taken with a grain of salt. Implementing strategies that result in the equitable receipt of COVID-19 vaccinations, though building vaccine confidence, raising awareness of the benefits of vaccination, and removing barriers to vaccination access among persons with disproportionately higher hospitalizations rates from COVID-19, including Black adults, is an urgent public health priority.
Immunogenicity and Reactogenicity of the Beta-variant Recombinant JAMA 326, 16291631 (2021). NMF, MC, GD, DDA, AMP, and ST handled project administration. Arthur Reingold, Jeremy Roland, Ashley Coates, California Emerging Infections Program, Oakland, California; Breanna Kawasaki, Rachel Herlihy, Isaac Armistead, Madelyn Lensing, Jordan Surgnier, Sarah McLafferty, Colorado Department of Public Health & Environment; Ann Basting, Tessa Carter, Maria Correa, Daewi Kim, Carol Lyons, Hazhia Sorosindi, Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut; Emily Fawcett, Katelyn Ward, Jana Manning, Asmith Joseph, Allison Roebling, Chandler Surell, Stephanie Lehman, Taylor Eisenstein, Suzanne Segler, Grayson Kallas, Marina Bruck, Rayna Ceaser, Annabel Patterson, Sabrina Hendrick, Johanna Hernandez, Hope Wilson, School of Medicine, Emory University, Georgia Emerging Infections Program, Georgia Department of Public Health, Veterans Affairs Medical Center, Foundation for Atlanta Veterans Education and Research, Atlanta, Georgia; Jim Collins, Shannon Johnson, Justin Henderson, Sue Kim, Alexander Kohrman, Lauren Leegwater, Val Tellez Nunez, Sierra Peguies-Khan, Michigan Department of Health and Human Services; Kayla Bilski, Kristen Ehresmann, Richard Danila, Jake Garfin, Grace Hernandez, Kieu My Phi, Ruth Lynfield, Sara Vetter, Xiong Wang, Minnesota Department of Health; Daniel M. Sosin, Susan L. Ropp, Sunshine Martinez, Jasmyn Sanchez, Cory Cline, Melissa Judson, Florent Nkouaga, Mark Montoya, New Mexico Department of Health; Sarah Lathrop, Kathy M. Angeles, Yadira Salazar-Sanchez, Sarah A. Khanlian, Nancy Eisenberg, Dominic Rudin, Sarah Shrum Davis, Mayvilynne Poblete, Emily B. Hancock, Francesca Pacheco, New Mexico Emerging Infections Program; Yassir Talha, Celina Chavez, Jennifer Akpo, Alesia Reed, Murtada Khalifa, CDC Foundation, New Mexico Department of Health; Suzanne McGuire, Kerianne Engesser, Nancy Spina, Adam Rowe, New York State Department of Health; Sophrena Bushey, Virginia Cafferky, Maria Gaitan, Christine Long, Thomas Peer, Kevin Popham, University of Rochester School of Medicine and Dentistry, Rochester, New York; Julie Freshwater, Denise Ingabire-Smith, Ann Salvator, Rebekah Sutter, Ohio Department of Health; Sam Hawkins, Public Health Division, Oregon Health Authority; Tiffanie Markus, Katie Dyer, Karen Leib, Terri McMinn, Danielle Ndi, Gail Hughett, Emmanuel Sackey, Kathy Billings, Anise Elie, Manideepthi Pemmaraju, Vanderbilt University Medical Center, Nashville, Tennessee; Amanda Carter, Andrea George, Andrew Haraghey, Ashley Swain, Caitlin Shaw, Laine McCullough, Mary Hill, Ryan Chatelain, Salt Lake County Health Department, Salt Lake City, Utah; Alvin Shultz, Robert W. Pinner, Rainy Henry, Sonja Mali Nti-Berko, CDC; Elizabeth Daly, Council of State and Territorial Epidemiologists. Accessed March 10, 2022. A previous study conducted before the Omicron-predominant period that showed increased risk for COVID-19associated hospitalization among certain racial and ethnic groups, including Black adults, and suggested the increased hospitalization rates were likely multifactorial and could include increased prevalence of underlying medical conditions, increased community-level exposure to and incidence of COVID-19, and poor access to health care in these groups (7).
Estimated Effectiveness of COVID-19 Vaccines Against Omicron or Delta Hospitalization of infants and children aged 0-4 years with laboratory-confirmed COVID-19COVID-NET, 14 states, March 2020-February 2022. J., Fireman. All adjustment variables were selected a priori based on prior work36. 4% of cases) without NHS numbers were excluded from our primary analysis. Most mothers (66.14%) were between ages 25 and <35 years, and more than a quarter (27.27%) were of Asian race, 5.16% were Black, 24.44% were of Hispanic ethnicity and 37.57% were White. PubMed In January 2022, unvaccinated adults and those vaccinated with a primary series, but no booster or additional dose, were 12 and three times as likely to be hospitalized, respectively, as were adults who received booster or additional doses. MMWR Morb Mortal Wkly Rep 2021;70:108893. Black adults accounted for a higher percentage of hospitalizations during the Omicron-predominant period (26.7%) than during the Delta-predominant period (22.2%, p = 0.05).